infection with helicobacter pyloriis the most common cause of stomach and duodenal ulcers. about more than 80 % of people are infected with h. pylori in developing countries. h. pyloriuses urease enzyme product “ammonia” in order to neutralize and protect itself from the stomach acidic condition and urease enzyme activity has been shown to be essential to the colonization of h. pylori. inhibito...

helicobacter pylori :28 µg/ml).   (h. pylori) infection leads to different clinical and pathological outcomes in humans, including chronic gastritis, peptic ulcer disease and gastric neoplasia and even gastric cancer and its eradiation dependst upon multi-drug therapy. the most effective therapy is still unknown and prompts people to make great efforts to find better and more modern natural or ...

urease enzyme has a crucial role in the persistent habitation of helicobacter pylori (h. pylori) that induces gastrointestinal diseases, in particular gastritis, duodenal, peptic ulcer, and gastric cancer. plants have long been utilized as the biggest source of substances with medicinal properties from natural origin and therefore result in less toxicity and adverse side effects upon usage. 15 ...

New series of spiroindeno[1,2-b]pyrido[2,3-d]pyrimidine-5,3′-indolines as new urease inhibitors were synthesized by the catalytic procedure in high yield and short reaction time. In this method, biacidic carbon was prepared as a novel heterogeneous acid and was subsequently used as an efficient catalyst in this synthesis. The inhibitory activities of synthesized compounds were tested against Ja...

New series of spiroindeno[1,2-b]pyrido[2,3-d]pyrimidine-5,3′-indolines as new urease inhibitors were synthesized by the catalytic procedure in high yield and short reaction time. In this method, biacidic carbon was prepared as a novel heterogeneous acid and was subsequently used as an efficient catalyst in this synthesis. The inhibitory activities of synthesized compounds were tested against Ja...

In this study the effects of Fe2O3 and Fe3O4 magnetic nanoparticles and EDTA on urease activity was investigated. The effect of nano-Fe2O3 and nano-Fe3O4 on urease activity were investigated. Urease activity was studies by UV-Vis spectrophotometry at 40 °C at pH = 7.2 using sodium phosphate as buffer. Measurements were carried out using 0.075 mg/ml of urease and a range of nano-Fe2O3 and nano-F...

new series of spiroindeno[1,2-b]pyrido[2,3-d]pyrimidine-5,3′-indolines as new urease inhibitors were synthesized by the catalytic procedure in high yield and short reaction time. in this method, biacidic carbon was prepared as a novel heterogeneous acid and was subsequently used as an efficient catalyst in this synthesis. the inhibitory activities of synthesized compounds were tested against ja...

in this study the effects of fe2o3 and fe3o4 magnetic nanoparticles and edta on urease activity was investigated. the effect of nano-fe2o3 and nano-fe3o4 on urease activity were investigated. urease activity was studies by uv-vis spectrophotometry at 40 °c at ph = 7.2 using sodium phosphate as buffer. measurements were carried out using 0.075 mg/ml of urease and a range of nano-fe2o3 and nano-f...

The study was composed of two parts. A one-factor design was adopted to investigate DMD, CPM, NDFD and ADFD of diet by total feces collection method in trial one. Twelve lambs were allotted randomly to 4 groups of 3 animals (replicates), which were fed with basal diet, basic diet plus 40 mg/kg urease inhibitor, urea diet, urea diet plus 40 mg/kg urease inhibitor. Experimental period consisted o...

In this paper, we evaluated the anti-Helicobacter pylori activity and the possible inhibitory effect on its associated urease by Palmatine (Pal) from Coptis chinensis, and explored the potential underlying mechanism. Results indicated that Pal exerted inhibitory effect on four tested H. pylori strains (ATCC 43504, NCTC 26695, SS1 and ICDC 111001) by the agar dilution test with minimum inhibitor...